Jack was a research specialist in the lab from August 2020 to July 2022. He graduated from Swarthmore College in May 2020 with a B.A. in Biophysics. In the future, he’s interested in exploring intersections of physics and biomedical research. When he’s not in lab, Jack enjoys being outside, cooking and catching up with friends! In 2022, Jack earned an NSF Graduate Research Fellowship. Jack went on to pursue his Ph.D. in Biology at MIT.

Publications

Copley, K.E., J.C. Mauna, H. Danielson, M. Ngo, L. Xie, A. Smirnov, M. Davis, L. Mayne, M. Linsenmeier, J.D. Rubien, B. Portz, B.L. Lee, H.M. Odeh, M. Hallegger, J. Ule, P. Pasinelli, Y. Poon, N.L. Fawzi, B.E. Black, C.J. Donnelly, B.K. Jensen, and J. Shorter. Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration. bioRxiv. doi: 10.1101/2024.12.14.628507. pdf file link

Guo, L.*^, J.R. Mann*, J.C. Mauna°, K.E. Copley°, H. Wang°, J.D. Rubien°, H.M. Odeh, J. Lin, B.L. Lee, L. Ganser, E. Robinson, K.M. Kim, A.C. Murthy, T. Paul, B. Portz, A.M. Gleixner, Z. Diaz, J.L. Carey, A. Smirnov, G. Padilla, E. Lavorando, C. Espy, Y. Shang, E.J. Huang, A. Chesi, N.L. Fawzi, S. Myong, C.J. Donnelly^, and J. Shorter^. (2023). Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. bioRxiv. doi:10.1101/2023.09.04.555754. pdf file link (*Co-first author. °Co-second author. ^Co-corresponding author).

Ervilha Pereira, P., N. Schuermans, A. Meylemans, P. LeBlanc, L. Versluys, K.E. Copley, J.D. Rubien, C. Altheimer, M. Peetermans, E. Debackere, O. Vanakker, S. Janssens, J. Baets, K. Verhoeven, M. Lammens, S. Symoens, B. De Paepe, S.J. Barmada, J. Shorter, J.L. De Bleecker, E. Bogaert, and B. Dermaut. (2023). C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD. Acta Neuropathol. 145(6):793-814. pdf file link

Ma, X.R., M. Prudencio, Y. Koike, S.C. Vatsavayai, G. Kim, F. Harbinski, A. Briner, C.M. Rodriguez, C. Guo, T. Akiyama, H.B. Schmidt, B.B. Cummings, D.W. Wyatt, K. Kurylo, G. Miller, S. Mekhoubad, N. Sallee, G. Mekonnen, L. Ganser, J.D. Rubien, K. Jansen-West, C.N. Cook, S. Pickles, B. Oskarsson, N.R. Graff-Radford, B.F. Boeve, D.S. Knopman, R.C. Petersen, D.W. Dickson, J. Shorter, S. Myong, E.M. Green, W.W. Seeley, L. Petrucelli, and A.D. Gitler. (2022). TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A. Nature. 603(7899):124-130. pdf file link

Hallegger, M.*, A.M. Chakrabarti*, F.C.Y. Lee*, B.L. Lee, A.G. Amalietti, H.M. Odeh, K.E. Copley, J.D. Rubien, B. Portz, K. Kuret, I. Huppertz, F. Rau, R. Patani, N.L. Fawzi, J. Shorter, N.M. Luscombe, and J. Ule. (2021). TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell. 184(18):4680-4696.e22. pdf file link (*Co-first author).

Marras, A.E., J.R. Vieregg, T.M. Ting, J.D. Rubien, and M.V. Tirrell. (2019). Polyelectrolyte complexation of oligonucleotides by charged hydrophobic-neutral hydrophilic block copolymers. Polymers. 11(1):83. pdf file link

Xiao, Q., J.D. Rubien, Z. Wang, E.H. Reed, D.A. Hammer, D. Sahoo, P.A. Heiney, S.S. Yadavalli, M. Goulian, S.E. Wilner, T. Baumgart, S.A. Vinogradov, M.L. Klein, and V. Percec. (2016). Self-sorting and coassembly of fluorinated, hydrogenated, and hybrid janus dendrimers into dendrimersomes. J. Am. Chem. Soc. 138(38):12655-12663. pdf file link